Other energetically unfavorable helical disruptions, are counteracted by internal hydrogen bonding between surrounding residues. Further bends or kinks are induced through Gly-Gly, Pro-Pro, or Gly-Pro segments, ensuring that the helical structure is disrupted. In general, the calculated tilt angle for each transmembrane helix (H) is 22 12?(Nyholm et al., 2007). In rhodopsin, the strongest helical
Ganization, any discontinuities with respect to Trp content could disrupt function during Trp starvation. In one other case, CT091 to CT087 encode five proteins, the first four of which have low p/P Trp ratios (0.28, 0.74, 0, and 0.72). However, the final translation product is a homolog of MalQ, which is, in fact, one of the highest-Trp-content proteins in chlamydia. This does not appear to be th
Anges in the phosphorylation state of proteins lead to specific cellular responses (Cohen, 2000; Moorhead et al., 2009; Pidoux and Tasken, 2009). Eukaryotic kinases themselves often require activation by phosphorylation (Nolen et al., 2004) and are distinguished by their target residue specificities, which for the purposes of this review are either serine/threonine or tyrosine residues (Olsen et a
Anges in the phosphorylation state of proteins lead to specific cellular responses (Cohen, 2000; Moorhead et al., 2009; Pidoux and Tasken, 2009). Eukaryotic kinases themselves often require activation by phosphorylation (Nolen et al., 2004) and are distinguished by their target residue specificities, which for the purposes of this review are either serine/threonine or tyrosine residues (Olsen et a
Anges in the phosphorylation state of proteins lead to specific cellular responses (Cohen, 2000; Moorhead et al., 2009; Pidoux and Tasken, 2009). Eukaryotic kinases themselves often require activation by phosphorylation (Nolen et al., 2004) and are distinguished by their target residue specificities, which for the purposes of this review are either serine/threonine or tyrosine residues (Olsen et a
Or example, transcription factor complexes such as the YAP/TAZ proteins together with p73 and p63 proteins (relatives of the better-known p53 tumor suppressor protein) constitute a critical transcriptional complex in which both protein partners can be regulated by JNKs. Specifically, the coactivator protein YAP1 is also subject to multisite phosphorylation that can be considered a complex phosphos
This domain is highly conserved between the two VRIs, i.e. 76.9 amino acid identity and 96.9 amino acid similarity.Comp Biochem Physiol Part D Genomics Proteomics. Author manuscript; available in PMC 2014 April 21.Tilden et al.PageReciprocal blasting of Dappu-VRI against all proteins curated in FlyBase identified VRI (Flybase no. FBpp0289297) as the most similar D. melanogaster protein to the Da
This domain is highly conserved between the two VRIs, i.e. 76.9 amino acid identity and 96.9 amino acid similarity.Comp Biochem Physiol Part D Genomics Proteomics. Author manuscript; available in PMC 2014 April 21.Tilden et al.PageReciprocal blasting of Dappu-VRI against all proteins curated in FlyBase identified VRI (Flybase no. FBpp0289297) as the most similar D. melanogaster protein to the Da