O challenges meeting a larger recruitment target [9]. Using a repeated measures analytic approach, we calculated that a sample size of 120 provided 83 power toDirectly Administered Therapy for HIVFigure 3. Average log10 HIV RNA (A) and change from baseline in log10 HIV RNA (B) over time, stratified by study arm. Directly administered antiretroviral therapy (DAART) is shown with square markers an
Ine for drug testing. Plasma was stored at a central repository for resistance testing. We monitored adherence with electronic pill bottle monitors (MEMS 6 TrackCap, AARDEX Group, Ltd., Sion, Switzerland) for the first 2 months after subjects started antiretroviral therapy (ART). We selected a single medication for monitoring according to the following hierarchy: dosed most frequently, combination
Studies evaluatingOns to the statistical methods used in this study.Studies evaluating the efficacy of directly administered antiretroviral therapy (DAART) for the treatment of HIV-infected individuals have yielded mixed results. A systematic review and meta-analysis of randomized trials by Ford and colleagues found no evidence overall for DAART benefit [1]. However, both the Ford anal
D a randomized trial to evaluate the efficacy of DAART in OTPs.for this trial and supporting CONSORT checklist are available as supporting information; see Checklist S1 and Protocol S1.Methods Design and Follow-upWe conducted a randomized controlled trial comparing 12 months of DAART to self-administered therapy (SAT) in five Baltimore OTPs - 3 hospital associated (1 Veterans Administration) and 2
Ine for drug testing. Plasma was stored at a central repository for resistance testing. We monitored adherence with electronic pill bottle monitors (MEMS 6 TrackCap, AARDEX Group, Ltd., Sion, Switzerland) for the first 2 months after subjects started antiretroviral therapy (ART). We selected a single medication for monitoring according to the following hierarchy: dosed most frequently, combination
Ine for drug testing. Plasma was stored at a central repository for resistance testing. We monitored adherence with electronic pill bottle monitors (MEMS 6 TrackCap, AARDEX Group, Ltd., Sion, Switzerland) for the first 2 months after subjects started antiretroviral therapy (ART). We selected a single medication for monitoring according to the following hierarchy: dosed most frequently, combination
D a randomized trial to evaluate the efficacy of DAART in OTPs.for this trial and supporting CONSORT checklist are available as supporting information; see Checklist S1 and Protocol S1.Methods Design and Follow-upWe conducted a randomized controlled trial comparing 12 months of DAART to self-administered therapy (SAT) in five Baltimore OTPs - 3 hospital associated (1 Veterans Administration) and 2