64188 - High DR Web Submission Directory - TractGlutamate cysteine ligase (GCL) deficiency is a rare autosomal recessive trait http://64188.org/story.php?title=tractglutamate-cysteine-ligase-gcl-deficiency-is-a-rare-autosomal-recessive-trait TractGlutamate cysteine ligase (GCL) deficiency is a rare autosomal recessive trait that compromises production of glutathione, a critical redox buffer and enzymatic cofactor. Patients have markedly reduced levels of erythrocyte glutathione, leading to hemolytic anemia and in some cases, impaired neurological function. Human glutamate cysteine ligase is a heterodimer comprised of a catalytic (GCLC Wed, 17 May 2023 14:59:20 UTC en