http://64188.org/story.php?title=tide-remains-compact202-or-displays-a-rather-independent-nterminus-195-in-particular Tide remains compact(202) or displays a rather independent Nterminus.(195) In particular, the latter simulation showed that the D23N mutation causes nonlocal perturbations of the WT conformational ensemble by increasing the -sheet propensity at the C-terminal region. This result is in agreement with the ss-NMR structure of a highly synaptic A1-40 toxic oligomer with a stable N-terminal -strand.(12 Wed, 28 Dec 2022 05:25:41 UTC en