http://64188.org/story.php?title=the-microglia-signal-transduction-pathways-mediating-the-neurotoxic-response-of-ab The microglia signal transduction pathways mediating the neurotoxic response of Ab demonstrated that mitogen-activated protein-kinase (MAPK) superfamily members ERK1/2 and p38 MAPK act as mediators [95-97]. Furthermore, several lines of evidence indicate the NF-B in microglia is stimulated by b-amyloid [98,99]. Activation of NF-B can stimulate transcription of genes expressing TNF-a, IL-1, IL-6, m Fri, 12 May 2023 00:38:52 UTC en