http://64188.org/story.php?title=ination-findings-given-the-inhibition-of-hsv-2-replication-observed-after-administration-4 Ination findings. Given the inhibition of HSV-2 replication observed after administration of tenofovir, it is biologically plausible that FTC/ TDF reduced the frequency or severity of ulcers. Unlike acyclovir, tenofovir does not require the presence of the herpes virus for drug activation, suggesting that it may suppress ulcers before phosphorylation occurs. However, topical dosing may be required Tue, 18 Jul 2023 23:37:42 UTC en