With heterotrimeric ) complexes in their inactive state (Bourne et al., 1991; Go( Gales et al., 2006), whereas activation of APP signaling should ?induce their dissociation. Conversely, if APP and APPL function as downstream targets for activated Go , we would not expect trimer. As shown in Figure 3J, them to associate with the antibodies against both the N- and C-terminal domains of APP coimmunop