Thus, the median times to virus acquisition compared to control monkeys were 8 weeks for VRC01, 13 weeks for 3BNC117 and 12.5 weeks for 10-1074. The pharmacokinetic profile of VRC01 was altered by introducing two amino acid mutations (M428L and N434S, referred to as "LS"), into its Fc domain, which increased its half-life in both plasma and tissues9. The neutralization activity of this VRC01 deriv