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Lk) and cryptochrome (cry) genes. Because the accumulation of PDP1 is delayed relative to that of VRI, the rhythms of clk and cry activation are antiphase (peaking in early day) to those of per and tim. In addition the CLK/CYC heterodimer also activates transcription of the clockwork orange (cwo) gene. The CLOCKWORK ORANGE (CWO) protein, a basic helix-loop-helix (HLH) repressor, in turn targets th
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