Edetomidine for 2A-adrenoceptors (Jansson et al., 1998). The selective stimulation of cellular pathways by different agonists acting through a single receptor been referred to by many names: stimulus trafficking (Kenakin, 1995a), functional dissociation (Whistler et al., 1999), biased agonism (Jarpe et al., 1998), biased inhibition (Kudlacek et al., 2002), differential engagement (Manning, 2002),