Ine for drug testing. Plasma was stored at a central repository for resistance testing. We monitored adherence with electronic pill bottle monitors (MEMS 6 TrackCap, AARDEX Group, Ltd., Sion, Switzerland) for the first 2 months after subjects started antiretroviral therapy (ART). We selected a single medication for monitoring according to the following hierarchy: dosed most frequently, combination

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Or media alone were added in duplicate wells, and the TER was measured at 30 min and 2, 4, 9, and 24 h. The epithelial resistance was expressed as follows :epithelial resistance = (/cm2) - the resistance of transwells without cells.HIV cell-free particles transcytosis the epithelial cell line HEC-1A was grown as a tight polarized monolayer on a permeable support of 0.4- -porediameter polycarbonate

N reference 356), and ion carriers (Fig. 6). Coral calcification is an extracellular process (177) that occurs within the ECM. It has been suggested that this medium is a colloidal gel matrix secreted by the calicoblastic cells (52, 71, 177); however, the physicochemical characteristics of this medium are still a matter of debate (for reviews, see references 6 and 357). Nevertheless, it must be al

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Es would most likely not have been affected. The measures of immune activation were not assessed at enrollment into the study cohort, and we therefore cannot make temporal inferences of a causal nature nor could we control for them in the multivariable Cox models. We used prevalence rate ratios (PRRs) to estimate the associations of interest as risk was our parameter of interest. We chose PRRs as

Istically significant period effect was found (P values i0.52). The primary statistical analysis gave an estimate of the reduction in saquinavir exposure when coadministered with rifabutin, as measured by AUC(0,8 h) and Cmax(0,8 h) of 47 (95 CI 30, 60 ) and 39 (95 CI 11, 59 ), respectively. Figure 1 illustrates the plasma concentrationtime profiles for saquinavir when administered alone (Treat

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