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Pectively, correspond to the type ii or iii microglial states described in the preceding paragraph. Further, the factors which cause polarization to M1 or M2, reinforce the maintenance of that phenotype in a cycle-like manner [8,9] (Figure 1). Increased M1 polarization is consistent with increased TNF-a observed in plasma and brain specimens in HAD and AD, and may play a role in the pathophysiolog
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Y and also visibly damaged subcortical areas [45,46]. Amyloid plaques in AD result from the deposition of amyloid beta (Ab) which is a putative pathogenic molecule in AD. Ab is the cleavage product of the amyloid precursor protein (APP) and APP mutations are associated with inherited forms of AD. The clinical implication or pathogenic consequences of brain amyloid deposition are still controversia
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At the University of North Carolina at Chapel Hill: JoAnn Kuruc, Alyssa Sugarbaker, Andrew Kerkhoff, Linh Ngo, Mary Bowman, Manzoor Cheema, Nancy Cheng, Shailesh Choudhary, and Kara Keedy; and at Duke University: Kara McGee, Lynn McNeil, and Bartlett Humphries. We would also like to thank Judith T. Lucas, Vicki C. Ashley, and R. Glenn Overman for expert technical assistance.Author ContributionsICM
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Tagonist `Compound A' [4-nitrobenzyl 1-(3(N-methylphenylsulfonamido)-3-phenylbutyl)piperidin-4-yl(vinyl)carbamate] [41,42] was kindly provided by Dr. Martin Springer at Merck Research Laboratories, Rahway, NJ. The anti-gp120 monoclonal antibody 48d, which recognizes an epitope that overlaps the coreceptor-binding site, was kindly provided by Dr. James Robinson (Tulane University Medical Center) [4
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