Rial. JAMA 2009, 301(15):1547?555. American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes Care 2004, 27(Suppl 1):s5 10. Grundy S, Brewer HBJ, Cleeman J, Smith SC, Lenfant C: Definition of metabolic syndrome report of the National heart, lung, and blood Institute/American heart association conference on scientific issues related to definition. Circulation 2004, 1

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Lpropane-1,3-diamine. Acknowledgements We especially thank the patients and surgeons, pathologists, and internists for their assistance in collecting tumor tissues and patients' clinical follow-up data. We thank Joan Bolt, Marion Meijer, Mieke Timmermans, Anita Trapman, and Wendy van der Smissen for their excellent technical support. This work was financially supported by VICI grant 918-66-615 (aw

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Either ESR1-positive and/or ESR2-low pT1 tumors.Introduction Estrogens influence the aggressiveness of breast cancer through their cognate nuclear receptors. In particular, the estrogen receptor-alpha (ERa) (ESR1) - present in tumor cells of about 70 to 75 of all breast tumors is considered crucial because of its proliferationinducing actions and for that reason is an important target for therap

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