Ability of this subunit. All AMPA receptors have another conserved cysteine residue just downstream of the QRN site (GluA1-QGC585DI, GluA2-C610, GluA3-C615, GluA4C611) that, when palmitoylated, increases AMPA receptor surface expression (Hayashi et al., 2005). The homomeric kainate receptor GluK2 undergoes palmitoylation of the cysteines SFC858SA and LKC871QR, both of which have no apparent effect

The microglia signal transduction pathways mediating the neurotoxic response of Ab demonstrated that mitogen-activated protein-kinase (MAPK) superfamily members ERK1/2 and p38 MAPK act as mediators [95-97]. Furthermore, several lines of evidence indicate the NF-B in microglia is stimulated by b-amyloid [98,99]. Activation of NF-B can stimulate transcription of genes expressing TNF-a, IL-1, IL-6, m

Coproteins [1]. Binding of gp120 to the receptor, CD4, on the target cell surface induces major conformational changes in the envelope glycoproteins [2]. These changes allow gp120 to bind the viral coreceptor, either CXCR4 or CCR5 [3?]. CD4 binding also induces the formation of a gp41 pre-hairpin intermediate, in which three hydrophobic grooves on the surface of a coiled coil formed by the heptad

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Er serum proteins). Despite this complexity of the in vivo model system, we identified and obtained differential quantitative information for peptides derived from 377 proteins involved in such processes as: actin filament morphogenesis, inflammation, substrate binding, oxidative stress, vesicular transport as well as neutrophil associated proteins, indicating early neutrophil infiltration. Qualit

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