Port, we show that soluble mimics of CD4 inhibit HIV-1 infection by prematurely triggering the viral envelope glycoproteins. The unstable activated state of the virus lasts only a few minutes, after which the virus loses the ability to infect cells. This novel strategy for inhibition may be generally applicable to other viruses besides HIV-1, some of which are also activated by binding to their re

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D if the HSV-2 diagnosis occurred at or after HIV seroconversion, and ulcers were excluded if they occurred at or after HIV seroconversion. We estimated the proportion of participants with 1 ulcer AE classified as Gradeor above (i.e., moderate, severe, or potentially life-threatening), 1 STI examination during which a perianal ulcer was detected, and 1 STI examination during which a groin ulcer

Cs of work, alcohol and drug consumption in sex workers according to workplace. Brazil, 2009. (N = 2,523) Workplace Variable Length of time working as a sex worker (years) Less than 1 1 to 3 4 to 9 10 to 19 20 or more Total Number of `tricks' per day 1 to 5 6 to 10 11 or more Total Charge (reais) 1.00 to 29.00 30.00 to 49.00 50.00 to 99.00 100.00 and over Total Frequency of alcohol consumption Nev

Used acyclovir or valacyclovir during study follow-up.HSV-2 prevalenceOf the 2,499 participants, 1383 (55.3 ) tested negative for HSV-2 at baseline, 892 (35.7 ) tested positive, 223 (8.9 ) had indeterminate tests, and one test was not done. Of the 223 with indeterminate tests at baseline, 114 (51.1 ) tested positive for HSV-2 infection at some point during follow-up. Factors associated with testin

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