Molecules including major histocompatibility complex (MHC) II and CD40 [15]. Microglia expressing MHC II induce CD4+ T cells to generate IFN-g and TNF-a [16]. In the case of both HAD and AD, this response is considered harmful to the brain and in both diseases TNFa is elevated to neurotoxic levels while only in HAD is IFN-g is prominently elevated [14]. In HIV associated dementia (HAD; also known

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Nal Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy ofNal Laboratory for Mole

Effects of inflammation on health during chronic HIV infection. Immunity 2013; 39: 633?45. 55. Kuller LH, Tracy R, Belloso W, De Wit S, Drummond F, Lane HC et al. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 2008; 5: e203. 56. Neuhaus J, Jacobs Jr DR, Baker JV, Calmy A, Duprez D, La Rosa A et al. Markers of inflammation, coagulation, and renal func

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Eptors. DC-SCRIPT is in this respect a unique co-regulator as we have shown that it enhances the activities of the nuclear retinoic acid receptor (RAR) and peroxisome proliferatoractivated receptor (PPAR) heterodimers, RARa/RXRa?2010 Sieuwerts et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creative

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