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No differences by randomization group in the proportion of participants with 1 STI examination during which a perianal ulcer (FTC/TDF 3.5 vs. placebo 4.7 , P = 0.37) or groin ulcer (FTC/TDF 2.5 vs. placebo 1.9 , P = 0.51) was identified; results were similar after excluding participants with a positive syphilis rapid plasma reagin test at the same visit. However, symptoms that prompted STI exam

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D role functioning (perfect score = 100) favoured the CXT arm (median change HAART = 0, CXT = +17; p=0.011). Improvement in pain (perfect score = 0, median change HAART = -16.7, CXT = -33.3; p=0.1) and overall QOL (median change HAART = 12.5, CXT = 16.7; p=0.08) were also greater in the CXT arm. Comparisons between arms were not statistically significant.NIH-PA Author Manuscript NIH-PA Author Manu

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