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Erapy, and had received methadone or buprenorphine for 3 weeks at the OTP with no plans to discontinue. We also required verbal approval from participants' HIV providers and confirmation of active insurance coverage for ART. Exclusion criteria included ART dosed more frequently than twice daily, use of liquid medication, and use of a regimen that was predicted to have fewer than 1.5 active drugs

Which proved to be more relevant in street FSW. Studies have shown that drug abuse is associated with a significantly higher risk of becoming infected with HIV, as it can influence unsafe sexual practices.23 The need for money to buy drugs is another factor which affects negotiations for safe sex.8,24 A study reviewing articles on FSW in Central Asia concluded that the HIV transmission risk factor

Port, we show that soluble mimics of CD4 inhibit HIV-1 infection by prematurely triggering the viral envelope glycoproteins. The unstable activated state of the virus lasts only a few minutes, after which the virus loses the ability to infect cells. This novel strategy for inhibition may be generally applicable to other viruses besides HIV-1, some of which are also activated by binding to their re

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Coproteins [1]. Binding of gp120 to the receptor, CD4, on the target cell surface induces major conformational changes in the envelope glycoproteins [2]. These changes allow gp120 to bind the viral coreceptor, either CXCR4 or CCR5 [3?]. CD4 binding also induces the formation of a gp41 pre-hairpin intermediate, in which three hydrophobic grooves on the surface of a coiled coil formed by the heptad