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Coproteins [1]. Binding of gp120 to the receptor, CD4, on the target cell surface induces major conformational changes in the envelope glycoproteins [2]. These changes allow gp120 to bind the viral coreceptor, either CXCR4 or CCR5 [3?]. CD4 binding also induces the formation of a gp41 pre-hairpin intermediate, in which three hydrophobic grooves on the surface of a coiled coil formed by the heptad
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Coproteins [1]. Binding of gp120 to the receptor, CD4, on the target cell surface induces major conformational changes in the envelope glycoproteins [2]. These changes allow gp120 to bind the viral coreceptor, either CXCR4 or CCR5 [3?]. CD4 binding also induces the formation of a gp41 pre-hairpin intermediate, in which three hydrophobic grooves on the surface of a coiled coil formed by the heptad
1
N Rai et al 2013, with 4429 instances of ASDs 1828 with and 2601 with no intellectual disability and 43,277 matched controls with no ASD identified in the Stockholm Youth Cohort. This study found that a history of maternal depression was associated with an enhanced danger of ASD inside the offspring adjusted OR1.49, 95 CI 1.08.08, and that antidepressant exposure SSRIs or nonselective monoamine r
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N Rai et al 2013, with 4429 instances of ASDs 1828 with and 2601 with no intellectual disability and 43,277 matched controls with no ASD identified in the Stockholm Youth Cohort. This study found that a history of maternal depression was associated with an enhanced danger of ASD inside the offspring adjusted OR1.49, 95 CI 1.08.08, and that antidepressant exposure SSRIs or nonselective monoamine r
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