Infection in vitro, this protein was tested for clinical efficacy in HIV-1-infected individuals; however, no effect on plasma viral loads was observed [13]. Further examination revealed that doses of sCD4 that were significantly higher than those achieved in the clinical trial were required to neutralize primary clinical isolates of HIV-1, in contrast to the relatively sensitive, laboratory-adapte

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Ine for drug testing. Plasma was stored at a central repository for resistance testing. We monitored adherence with electronic pill bottle monitors (MEMS 6 TrackCap, AARDEX Group, Ltd., Sion, Switzerland) for the first 2 months after subjects started antiretroviral therapy (ART). We selected a single medication for monitoring according to the following hierarchy: dosed most frequently, combination

Nt populations [6,7]. Opioid treatment programs (OTPs) provide a potential framework for DAART because patients visit multiple times each week to receive opioid agonist medication. Moreover, maintenance treatment at OTPs permits prolonged DAART, which is difficult in models based on outreach workers. Based on promisingDirectly Administered Therapy for HIVFigure 1. Study screening, enrollment, and