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Ipt Author Manuscript Author Manuscript Author ManuscriptExtended Data Figure 2. Development of anti-MAb immune responses in recipients of antiHIV-1 bNAbsNature. Author manuscript; available in PMC 2016 November 29.Gautam et al.Pagea, b, c, d, Longitudinal analysis of anti-VRC01, anti-3BNC117, anti-10-1074 and antiVRC01-LS antibody responses respectively, following a single intravenous infusion of

T the level of gene expression act cooperatively to establish and maintain HIV latency. In conclusion, our study reveals that TI represents a key mechanism that antagonizes proviral gene expression to promote the latency of HIV. Furthermore, it demonstrates several means that could be used to counteract TI for reactivating latent HIV. Future mechanistic studies linking TI and other transcriptional