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Nopathy in the homosexual male. Am J Surg Pathol 9: 287?97. 36. Wood GS (1990) The immunohistology of lymph nodes in HIV infection: a review. Prog AIDS Pathol 2: 25?2. 37. Alter G, Teigen N, Ahern R, Streeck H, Meier A, et al. (2007) Evolution of innate and adaptive effector cell functions during acute HIV-1 infection. J Infect Dis 195: 1452?460. 38. Alter G, Teigen N, Davis BT, Addo MM, Suscovich
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Tance use), and immunologic measures in plasma and CSF. 2. Materials and methods Northwestern University Institutional Review Board approved this investigation, which was conducted in compliance with U.S. federalhttp://dx.doi.org/10.1016/j.nicl.2015.07.012 2213-1582/?2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.or
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Tance use), and immunologic measures in plasma and CSF. 2. Materials and methods Northwestern University Institutional Review Board approved this investigation, which was conducted in compliance with U.S. federalhttp://dx.doi.org/10.1016/j.nicl.2015.07.012 2213-1582/?2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.or
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Ents/the study: MCL MAM KKH TCG SA DCP GT GS JS DMM BFH. Analyzed the data: MAM KKH DJM JDA TCG SA BBH DCP MC GT PAG HXL BFH. Collected data/did experiments for the study: MCL MAM KKH DJM JFW JDA TCG SA BBH NAV SP DCP MC GT GS JE NJS CBH HXL MM GHK BFH. Enrolled patients: MC PAG GS JE CBH MM DMM. Wrote the first draft of the paper: MCL BFH. Contributed to the writing of the paper: MCL MAM BBH NAV
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Owed a direct correlation between microglial activation/infection and cognitive decline [19]. Studies have found microglial HIV infection as central in exacerbating HIV dementia [20,21]. Importantly, neuronal dysfunction and death in HIV infection results from cytokine stimulation, but especially several cytokine-mediated apoptotic mechanisms emanating from microglia. Thus microglial cytokine prod
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Port, we show that soluble mimics of CD4 inhibit HIV-1 infection by prematurely triggering the viral envelope glycoproteins. The unstable activated state of the virus lasts only a few minutes, after which the virus loses the ability to infect cells. This novel strategy for inhibition may be generally applicable to other viruses besides HIV-1, some of which are also activated by binding to their re
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