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Er serum proteins). Despite this complexity of the in vivo model system, we identified and obtained differential quantitative information for peptides derived from 377 proteins involved in such processes as: actin filament morphogenesis, inflammation, substrate binding, oxidative stress, vesicular transport as well as neutrophil associated proteins, indicating early neutrophil infiltration. Qualit

Rt TC, Marino PN, Oh JK, Smiseth OA, et al: Recommendations for the evaluation of left ventricular diastolic function by echocardiography. J Am Soc Echocardiogr 2009, 22:107?33. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories: ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002, 166:111?17. Rutten FH, Walma EP, Kruizinga GI, Ba

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Es would most likely not have been affected. The measures of immune activation were not assessed at enrollment into the study cohort, and we therefore cannot make temporal inferences of a causal nature nor could we control for them in the multivariable Cox models. We used prevalence rate ratios (PRRs) to estimate the associations of interest as risk was our parameter of interest. We chose PRRs as

Espite successful HCV eradication. Other complications such as development of carcinoma may be more readily amenable to more rapid risk reduction with antiviral therapy. Further studies with long periods of follow-up will be needed to address these questions. Our study has several limitations. Not all patients had measures of immune activation documented in their study records and were therefore e

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