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S in humans (48?0). However, this was the first demonstration that human DCs could be conditioned by cytosolic DNA to endow in vitro primed na e CD4+ T cells with killing capacity. In addition, in the presence of T cells, dsDNA-activated DCs, but not LPS- or cocktail-activated DCs, activated B cells to produce complement fixing IgG1 and IgG3 but not non-complement fixing IgG2 and IgG4 antibodies.

Nd 4 events. Using this scale, grade 1 and 2 denote mild to moderate symptoms, grade 3 denote serious symptoms and grade 4 denote life-threatening events requiring significant clinical intervention. Grade 5 denotes death (DAIDS 2009). Search methods for identification of studies See: HIV/AIDS Collaborative Review Group search strategy. The search aimed to be comprehensive and included published an