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Analysis (MFA), kinetic flux profiling (KFP), and kinetic modeling (KM). The merits and drawbacks of the first three methods were discussed previously (562). The pros and cons of various types of models, including kinetic models, were dealt with previously (563, 564). FBA relies on an objective function, which is mostly not validated (565). Also, FBA cannot predict metabolite concentrations, becau

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Either ESR1-positive and/or ESR2-low pT1 tumors.Introduction Estrogens influence the aggressiveness of breast cancer through their cognate nuclear receptors. In particular, the estrogen receptor-alpha (ERa) (ESR1) - present in tumor cells of about 70 to 75 of all breast tumors is considered crucial because of its proliferationinducing actions and for that reason is an important target for therap