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Coproteins [1]. Binding of gp120 to the receptor, CD4, on the target cell surface induces major conformational changes in the envelope glycoproteins [2]. These changes allow gp120 to bind the viral coreceptor, either CXCR4 or CCR5 [3?]. CD4 binding also induces the formation of a gp41 pre-hairpin intermediate, in which three hydrophobic grooves on the surface of a coiled coil formed by the heptad

N reference 356), and ion carriers (Fig. 6). Coral calcification is an extracellular process (177) that occurs within the ECM. It has been suggested that this medium is a colloidal gel matrix secreted by the calicoblastic cells (52, 71, 177); however, the physicochemical characteristics of this medium are still a matter of debate (for reviews, see references 6 and 357). Nevertheless, it must be al

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Es would most likely not have been affected. The measures of immune activation were not assessed at enrollment into the study cohort, and we therefore cannot make temporal inferences of a causal nature nor could we control for them in the multivariable Cox models. We used prevalence rate ratios (PRRs) to estimate the associations of interest as risk was our parameter of interest. We chose PRRs as

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